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KMID : 0921620110410020131
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Journal of Bacteriology and Virology
2011 Volume.41 No. 2 p.131 ~ p.132
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Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation
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Koh Young-Sang
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Abstract
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Toll-like receptor 9 binds to DNA from bacteria or viruses and activates a signaling pathway that leads to the induction of proinflammatory cytokines and type I interferon. Adaptor complex AP-3 was required for TLR9 trafficking and the production of type I interferon but not for proinflammatory cytokines. This suggests that TLR9 signaling is regulated by the subcellular localization of the receptor
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KEYWORD
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Toll-like receptor 9, Membrane trafficking, Adaptor complex AP-3
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